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However, accumulating data indicate that the ability of the sperm to fertilize and subsequently enable the development of a normal fetus is dependent on many other co-factors in addition to the basic semen parameters, like DNA breakage and genetic changes in the sperm, which cannot be diagnosed in a simple semen analysis, he said

Just because a patient has a SNP that might predispose them to a deficiency in methylation, it does not mean they actually have impaired methylation

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Cholinergic receptors are located in several brain regions notably the midbrain tegmentum, the striatum, nucleus accumbens and the ventral tegmentum (VTA)