As water-soluble nutrients, the body does not store folic acid or vitamin B12 so they must be consumed daily through the diet or supplementation to assure adequate amounts are available for optimal health
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Therefore, it is necessary to follow strategies to minimize drug resistance and maximize antitumor activity (Wang et al., 2019)
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Over the past two decades, advances in our understanding of gut-derived hormonesparticularly incretinshave reshaped how we treat these conditions