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This is likely due to cytisines low lipophilicity and the possible presence of an unknown brain efflux mechanism

Cigarettes provide rapid nicotine spikes followed by quick drops, contributing to the addiction cycle

Adult smokers transitioning from cigarillos or small cigars usually prefer freebase nicotine at 6-12mg in a higher-VG ratio for fuller vapor production, which more closely mimics the cigar draw

Young people are the most vulnerable group to initiate use of e-cigarettes

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7 For example, research shows that while smoking marijuana still remains the primary method of consumption in the United States for adolescents, the use of edibles among them continues to increase