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As of March 2026, two trials are actively recruiting new participants: the Maintenance trial (NCT06859268, testing dose reduction after initial weight loss) and a new enrollment trial (NCT07232719, 250 participants with obesity or overweight)

Carnitine measurement in this Guideline is based on blood carnitine 2 fractions testing using the enzyme cycling method that is unfortunately not used outside of Japan but very useful to diagnose carnitine deficiency and insufficiency in daily practice

Among the seven included studies, four were at low risk [33,34,35,36], and three had a moderate risk [23, 25, 37]

Cystine is transformed into cysteine, a precursor of GSH, which is crucial for detoxifying lipid peroxides (130)

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Blood is drawn, then processed to make the platelets more concentrated