The clinical investigations of results can correct the medical program
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These landmark studies showed that mice with adipose-tissue-specific NNMT knockout remained lean when fed high-fat diets that caused wild-type mice to become obese, and that these protected mice had increased energy expenditure, enhanced fatty acid oxidation, improved glucose tolerance, and elevated NAD+ levels in adipose tissue
It is possible that the effects are additive, that they are redundant, or that combining approaches produces unexpected outcomes
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