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Furthermore, the authors proposed a mechanism-of-action, whereby 2 -agonists stimulate adenylyl cyclase, leading to cyclic AMP accumulation, activation of protein kinase G, and opening of large conductance calcium-activated potassium (BK Ca ) channels, thereby inhibiting sensory nerve depolarisation

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To protect yourself from bites: use an approved bug spray (insect repellent) on exposed skin wear light-coloured, loose clothing made of tightly woven materials like nylon or polyester wear socks and closed-toe shoes sleep under mosquito netting if youre outdoors or staying in places that arent fully enclosed do a full body tick check on yourself, your children, your gear, and any pets youre travelling with when you return from outdoor activities Insect bite and pest prevention Personal insect repellents Chikungunya There is a risk of chikungunya in this country