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Notably, it has been shown that the expression levels of Parkin are very low or even absent in many cancers, including gliomas [16, 17]
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Non-etheless, ample data link nicotine dependence to the effect of nicotine on the brain reward system through increasing dopamine secretion in neurons originating in the ventral tegmental area (VTA) that project to the nucleus accumbens (NAc) and many other brain regions (Schilstrm et al., 1997
& Lambertucci, S
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