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A study by the Respiratory Diseases Institute of China Medical University found that Macrophages (AM), polymorphonuclear neutrophils (PMN), and elastase in the lower respiratory tract of smokers were significantly higher than in non-smokers

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Chemical properties of nicotine and other tobacco-related compounds

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And as smoking increases, the damage becomes much more substantial, with a much higher risk of developing smoking-related illnesses. Beyond the lungs, smoking harms the cardiovascular system from the earliest stages, damage that begins at the level of the blood vessels themselves and can end in life-threatening events