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[79] demonstrated that Plasma sE-cadherin levels were significantly lower in patients with COPD and symptomatic smokers than in healthy smokers and healthy non-smokers, and sE-cadherin levels were associated with the severity of airflow limitation in COPD and symptomatic smokers plasma

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"Spatial, temporal, and demographic patterns in prevalence of chewing tobacco use in 204 countries and territories, 19902019: a systematic analysis from the Global Burden of Disease Study 2019"

If not..you are welcome to tag along my experience as that was my eye opening revaluation as I have come to accept as my normal lately