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However, it undeniably contributes to itespecially through dehydration, hormone disruption, chemical exposure, and inflammation

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Airway epithelial barrier dysfunction not only impairs the physical barrier activity of airway epithelium, but further exposes sub-epithelial layers to exogenous substances, leading to a series of pathological processes such as airway inflammation, airway remodeling, airway hyperresponsiveness and increasing the rate of COPD exacerbation [7, 8]

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[238] It was not immediately clear whether Good was legally obligated to comply with ICE's orders