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The gut-brain axis in autism spectrum disorder: a focus on the metalloproteases ADAM10 and ADAM17

In: Scriver CR, Beaudet AL, Sly WS, Valle D (eds) The Metabolic and Molecular Bases of Inherited Disease

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Additionally, other animal studies have shown that rapamycin reverses hair graying, prevents muscle weakness, improves gut health, inhibits bone loss, improves reproductive health, and mitigates cognitive impairment

Trial results are interim where indicated

Our defense against oxygen radicals relies on the enzymes of the glutathione/thioredoxin antioxidant system, which inactivate ROS and NOS, glutathione peroxidase detoxifies peroxides, including H 2 O 2 and peroxides that are generated during the oxidation of membrane lipids