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For researchers building a comprehensive IGF axis research workflow, the standard approach is to use IGF-1 LR3 as the primary tool for sustained IGF1R activation studies, native IGF-1 for short-pulse studies where IGFBP biology is itself the research question, and DES IGF-1 for the narrow set of experiments requiring receptor activation with rapid washout

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5 Additionally, the osmotic gradient does not readily explain the neovascularization and retinal features of diabetic retinopathy

Ernst, J