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Lower-BMI tiers require a more specific condition because CMS structured the program so the patients most likely to benefit clinically (those with the highest combined disease burden) qualify

Kalialis LV, Drzewiecki KT, Klyver H

This approach is for people with a BMI above 50, severe diabetes or who'd like to lose 200 pounds or more

rather, they promote generalised weight loss through reduced energy intake and metabolic changes

It can upregulate and downregulate over 4,000 genes, and its copper binding properties also exert many positive effects [2]

With tirzepatide, the usual starting dose is 2.5 mg once weekly, with increases every ~4 weeks if tolerated, up to a maintenance dose of 5-15 mg weekly for weight loss