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The discovery that NNMT expression is dramatically elevated in adipose tissue of obese humans and animal models, and that NNMT inhibition or knockdown prevents diet-induced obesity and improves metabolic health, has catalyzed intense research interest in NNMT as a therapeutic target for obesity, metabolic syndrome, and related conditions

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J Comp Neurol, 524:90-118

Malabsorption of vitamin B12 resulting from structural or functional damage to the stomach, where intrinsic factor is secreted, or to the ileum, where intrinsic factor facilitates vitamin B12 absorption

The success of Novo Nordisks Rybelsus has once again demonstrated that simpler formulationsthose containing a single, well-chosen permeation enhancer such as SNACare often the most viable from an industrial perspective, primarily due to their scalability and manufacturing feasibility

So I think there's like workarounds but slightly different topic