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Methane and constipation-predominant irritable bowel syndrome: entwining pillars of emerging neurogastroenterology

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As always in pharma, there are unforeseen consequences, and either company might underperform expectations

Studies in DSS and TNBS mouse models as well as in vitro experiments have shown that amino acids not only serve as substrates for energy production and biosynthesis, but also influence the M1/M2 macrophage balance through metabolic pathways, thereby regulating intestinal inflammation

Separately, GLP-1 drugs appear to reduce alcohol cravings: a May 2026 Lancet trial found semaglutide cut heavy drinking days by 41% versus 26% on placebo in adults with alcohol use disorder and obesity

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