Efficacy and safety of tirzepatide in type 2 diabetes: SURPASS-2 trial
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As a member of the G proteincoupled receptor (GPCR) family, GLP-1R features a large extracellular domain responsible for ligand recognition and binding ( The widespread expression of GLP-1R suggests that GLP-1 plays pleiotropic physiological roles beyond insulin secretion
84-87 In fructose-induced hyperuricemic rodents, quercetin, rutin, kaempferol, myricetin, and puerarin all significantly reduced blood uric acid to levels equivalent to healthy control animals
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In select cases, temporary dose reduction or treatment interruption may be necessary while investigating symptoms, though this decision should be made collaboratively between patient and provider, weighing the benefits of continued therapy against symptom burden
