4 Inflammasome-mediated liver injury: DAMPs released from stressed hepatocytes, damaged mitochondria, and necrotic liver cells activate inflammasome sensors, triggering the oligomerization and activation of inflammasome components
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Indeed, circulating autoantibodies may detect modified forms of these antigens, potentially enhancing identification of those subjects who test negative to assay for the unmodified autoantigen (86, 134, 135)
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