Although they primarily target joints, central nervous system, gastrointestinal tract, and multiple systemic organs, respectively, a common hallmark across these diseases is a significant disruption in the balance of T cell subsets, particularly a dynamic imbalance between Th17 cells and Treg cells ( Figure 2 )
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There is a pressing need for standardized diagnostics and longitudinal studies to clarify the temporal relationship between microbiome changes and disease onset, as well as to identify reliable microbial or metabolic biomarkers for early detection and targeted intervention (Dai et al., 2024
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Recent findings have indicated that levels of the atypical methyltransferase METTL1 are elevated in cancer cells, thereby promoting glutamine synthase (GLUL) expression in an m6A-dependent manner, which in turn facilitates cancer cell proliferation [44]
