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14 The most common adverse effects associated with oral creatine include 14,16 Dehydration Diarrhea Gastrointestinal upset Muscle cramps Water retention leading to weight gain It is rare to experience severe adverse effects when taking creatine, however, the following may occur 14 Interstitial nephritis Renal insufficiency Rhabdomyolysis Venous thrombosis Prior to beginning creatine supplementation, individuals with the following conditions should avoid its use until first discussed with their physician: 16 Bipolar disease (may increase mania) Diabetes Kidney disease Liver disease Parkinsons disease, especially in combination with caffeine (may accelerate progression of disease) Pregnant or breastfeeding A pharmacy technician should refer to the pharmacist if the patient 14,16 Has a disease state or condition listed above Asks for a recommendation on which creatine supplement to use Has questions or concerns regarding possible drug interactions or adverse effects Has specific questions about dosing based on their condition, disease state, or current medications or use of other supplements Common Misconceptions People share a considerable amount of information about dietary supplements like creatine online and on other platforms, but some of this information can be inaccurate or misleading

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Autonomous growth and function of cultured thyroid follicles from cats with spontaneous hyperthyroidism

Hiraga, S., Sasaki, K., Ito, H., Ohashi, Y

Sage, which has been traditionally used in Iranian medicine, was found to restore insulin sensitivity and reduce BMI in PCOS patients [34]