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Down-regulation of SARM1 and TRAF6 reduce the level of PINK1 and then recruits Parkin to the impaired mitochondria, indicating that SARM1 plays a crucial role in mitophagy via modulating PINK1

55 Chem Biol Interact

doi: 10.3389/fmicb.2019.00159 93 ThioCLChiPYLaiACChangYJ

It probably is not the holy grail of fat loss, however, for good enough fat loss it certainly is a drug to consider

Oh, and how much berberine to take, should you decide to start the supplement

To compensate for the resulting ATP loss, the PBMC increase their glycolytic activity, which is reflected in increased ECAR values of all glycolytic variables in the Mito Stress Test