Ive previously reviewed the GLP-1 family of peptides extensively (here and here) and it seems every week there is a new potential use case, such as we recently saw for migraine and the oneAlzheimers disease that we await with a very high level of anticipation in September from the 2 large trials with semaglutide
To further testify our hypothesis, we treated the TAC rats with semaglutide and inhibitor of mitophagy (HCQ)
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Moving from 0.25 mg to 0.50 mg and from 0.50 mg to 1.0 mg represent the steepest relative dose jumps in the titration schedule (100% increases each time)
This is a major point of confusion in the GLP-1 fertility conversation: just because these drugs improve metabolic markers doesnt mean theyre safe or effective when actively TTC
External resources New England Journal of Medicine: Retatrutide Phase 2 trial results PMC meta-analysis: Comparative efficacy of GLP-1 receptor agonists Nature Medicine: Retatrutide for MASLD randomized Phase 2a trial Eli Lilly: TRIUMPH-4 Phase 3 retatrutide results press release New England Journal of Medicine: Tirzepatide versus semaglutide head-to-head trial In case I do not see you, good afternoon, good evening, and good night