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Metabolite profiles were examined prior to treatment initiation with methotrexate (MTX) in 82 patients with early RA, which revealed homocysteine, glycerol-3-phosphate, and 1,3-/2,3-DPG as models for predicting the response to MTX with an AUC of 0.81 (95% CI: 0.720.91) (101)

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