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Hormonal contraceptives containing synthetic oestrogen can contribute to sustained elevation of oestrogen levels, which may exacerbate histamine-related symptoms in susceptible women, including worsening of allergies, skin reactions, and histamine intolerance more broadly

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Monitoring renal function is advisable, particularly in patients experiencing significant gastrointestinal symptoms that could lead to dehydration

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If you took them at the same time, your blood sugar could become dangerously low