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Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

Chu et al., 2006)

In HT-22 (mouse hippocampal neurons cells) cells, Fer-1 notably decreases both cytoplasmic and lipid ROS levels, counteracts glutamate-induced suppression of GSH and GPX activity and protects against oxidative toxicity

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Adverse events and discontinuations were recorded