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In a mouse model of UUO, treatment with finerenone (3 or 10 mg/kg) once daily starting with the first dose 2 days before UUO, decreased pathological myofibroblast accumulation and collagen deposition along with decreased expression of kidney fibrosis markers PAI-1 and naked cuticle 2 (NKD2) [197]

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Obesity and visceral adiposity are key drivers of HFpEF development and progression, and this may be even more amplified in women, who represent the majority of people with the disease, and bear a heavier burden of symptoms and physical limitations due to HFpEF, says Mikhail Kosiborod, MD, FACC, senior author of the study and a cardiologist at Saint Lukes Mid-America Heart Institute

The medication may simultaneously slow food transit and increase the bacterial population responsible for sulfur gas production

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