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Because the hinge and latch hypothesis predicts that the wild-type-mutant heterodimer does not support Nrf2 ubiquitination, a heterozygous missense mutation would result in the 75% reduction of Keap1 activity

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Zhang LM, Wang MH, Yang HC et al (2019) Dopaminergic neuron injury in Parkinsons disease is mitigated by interfering lncRNA SNHG14 expression to regulate the miR-133b/ -synuclein pathway

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Nature Communications, 16 (1), 1-15

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