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It does this by mimicking the effects of the GLP-1, GIP and glucagon receptors, which are natural hormones that makes humans feel full from eating much smaller portions of food
Dysregulation of peptide hormones contributes to conditions such as gastroparesis, inflammatory bowel disease, and malabsorption syndromes
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This receptor is responsible for regulating appetite and food intake, and activating it can lead to a reduction in appetite and food cravings
The GLP1 receptor agonist exenatide reduces serum TSH by its effect on body weight in people with type 2 diabetes
Consistent with this use of a reporter mouse together with a number of validation approaches the GLP-1R was identified in chief cells, parietal cells and Brunners glands ( 125 I-labeled GLP-1 also demonstrated a strong signal in stomach parietal cells, basolateral epithelial cells in the duodenum, Brunners glands and the myenteric nerve plexus (Pyke et al., 2014)
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