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When GLP-1 binds to its receptor, it amplifies the insulin signaling pathway, causing increased phosphorylation of insulin receptor substrates and activating the PI3K/Akt pathway, which ultimately results in enhanced glucose uptake, utilization within the liver, and reduced production of glucose (gluconeogenesis)

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For research reproducibility, the details that matter are purity and documentation, because an impure or mislabelled compound makes results meaningless

Many physicians also reportedly shifted to off-label prescriptions