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Subsequent secondary-source reviews have proposed candidate interactions modulation of GABAergic and glutamatergic tone, possible NMDA-receptor involvement, peripheral 1-adrenergic effects but these have not been replicated in primary studies that establish direct binding or saturable transduction at a defined receptor

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For non-normally distributed groups, the Kruskal-Wallis test was applied and Dunns post-hoc test was performed for pairwise differences

Each peptide has specific stability requirements, and combining them can cause aggregation, degradation, or altered pharmacokinetics