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Nevertheless, as the simultaneous activation of GLP-1 and GIP receptors in preclinical models results in greater WL and glucose-lowering efficacy compared to activation of each receptor alone [38,39,40], the interest for the development of unimolecular GLP-1 and GIP RA was increased, despite that this additive effect in food intake and glycaemia was not observed in some acute clinical studies [41, 42]
Others add less water for "stronger" doses, making precise measurement more difficult
Hepatology 56 , 21882198 (2012)
NaBPC157 was given intravenously (i.v.)
In these cases, B12 injections can bypass the digestive system and deliver the vitamin directly into the bloodstream
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