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Stop treatment and call a healthcare provider if you notice: Severe swelling in your hands, feet, or face Chest pain or shortness of breath Sudden vision changes Signs of an allergic reaction (rash, throat swelling, trouble breathing) Significant mood swings or depression Why Do These Side Effects Happen

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In general, natural metabolic pathways in host bacteria cannot meet practical demands, therefore, one major application of engineering is to upregulate, downregulate or delete relative genes to redirect the metabolic pathway, achieving incremental production of goal products and minimizing by-products

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Others continue at their effective dose indefinitely

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Cureus 12 , e11735 (2020)

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