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Notably, GLP-1RAs slow the transit time of the gastrointestinal (GI) tract and suppress appetite, which could displace nutrient intake and result in mineral and vitamin deficiencies

Source: diet.mayoclinic.org Several factors contribute to how fast semaglutide starts working

People using pharmaceutical GLP-1 drugs who want microbiome support alongside their medication

And, of course, achieving and maintaining mood stability is at the heart of the challenge of living with bipolar disorder

Circulation 2011;123:1098e107

The article names significant kidney or liver disease, diabetic retinopathy, and active gallbladder disease as needing careful evaluation before starting, on top of the contraindications it lists: personal or family history of medullary thyroid cancer and multiple endocrine neoplasia syndrome type 2