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Individuals with B12 deficiency, which can occur due to dietary restrictions (e.g., vegan or vegetarian diets), gastrointestinal disorders affecting absorption, older age, or certain medical conditions that interfere with B12 absorption

The strongest clinical signal sits with triglycerides and the total cholesterol-to-HDL ratio, both driven by visceral fat reduction rather than a direct pharmacological effect on lipids

Davis, C

This difference influences dosing frequency in published animal protocols

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doi: 10.1038/s41551-019-0435-y 52 YuXShouWMahajanBKHuangXPanH