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Arcuate GLP-1 receptors regulate glucose homeostasis but not food intake

These studies indicate that GLP-1 modulates the release of several neurotransmitters including serotonin, dopamine, GABA, and glutamate, which may regulate depressive-like behaviors

Zhou Y, Zhang W, He C, Shu C, Xu X, Wang H, et al

doi: 10.3389/fphar.2025.1683279 Received 10 August 2025 Revised 16 October 2025 Accepted 17 October 2025 Published 14 November 2025 Volume 16 - 2025 Edited by Irina Ielciu, University of Medicine and Pharmacy Iuliu Hatieganu, Romania Reviewed by Prabhat Upadhyay, Massachusetts General Hospital and Harvard Medical School, United States Ashish Ranjan Sharma, Hallym University, Republic of Korea Karthi Natesan, Rural Development Administration, Republic of Korea Sidra Ilyas, Gachon University of Medicine and Science, Republic of Korea Updates Copyright 2025 Ouyang, Ma, Zhou, Tang, Li, Qing, Lei, Huang, Liu and Zhang

Studies describe

More serious but rare adverse effects include pancreatitis and gallbladder disease