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Thioredoxin-interacting protein (TXNIP), a redox-sensitive regulator, binds and inhibits thioredoxin, thereby promoting oxidative stress and increasing intracellular reactive oxygen species (ROS) 19

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A scoping review in Cureus (2025) added important context: dual-acting agonists like tirzepatide which targets both GLP-1 and GIP receptors produced greater reductions in weight and insulin sensitivity than GLP-1-only agents

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Some common side effects include: Anorexia Vomiting Headaches Diarrhea Nausea Storage Store at controlled room temperature