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When hepatic lipid export is impaired, triglycerides accumulate in liver cells (hepatic steatosis), which disrupts insulin signaling and shifts metabolism toward fat storage rather than fat oxidation

Peptidase activity also declines moderately with age, though this effect is less pronounced than the renal component

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Changes in anti-inflammatory adipokines Serum adiponectin levels increase with age

Importantly, the Safe System approach places the emphasis on making the transport system safe for people using it, rather than on how people can use the system more safely