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Similar content being viewed by others Introduction Heart failure (HF) affects approximately seven million adults in the United States, with one-third to half experiencing heart failure with preserved ejection fraction (HFpEF) [1,2,3,4]

Skin whitening treatments are sought after not only for cosmetic reasons but also to address issues such as hyperpigmentation, dark spots, and uneven skin tone

Such insights drive pharmacometabolomics, nutritional studies and translational biomarker programmes

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Variants in FTO (fat-mass and obesity-associated), GLP1R (the GLP-1 receptor itself), MC4R (a satiety and energy-balance receptor), and TCF7L2 (tied to glucose handling and GLP-1 secretion) describe the metabolic terrain a clinician is prescribing into

The samples were immediately transferred to a low-speed centrifuge at 3000 rpm for 10 min to obtain the supernatant