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G6PD catalyzes the rate-limiting step of the PPP, effectively diverting G6P away from glycolysis toward 6-phosphogluconate, thereby promoting NADPH generation and glutathione synthesis ( Figure 6B )

Hoagland, William, Anand Parekh, MD, Geoffrey St

The article also notes that a change in how well the medication seems to work has several possible explanations

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