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We chose to focus on SLC7A11 as playing a critical role in intracellular GSH levels, targeting SLC7A11 with erastin

All compounds referenced in this article are for research use only

Metabolic rate generally tracks with body weight

In contrast to the animal lung function data ( cf

Case presentation SL was a 44 year old Caucasian male with a past medical history of severe morbid obesity (BMI 99), heart failure with preserved ejection fraction, oxygen-dependent obesity hypoventilation syndrome (OHS), chronic non-healing leg wounds, anemia, uncontrolled hypertension on 2 anti-hypertensive agents, limited mobility, and major depressive disorder who presented to an academic medical center for treatment of acute on chronic diastolic heart failure due to progressive dyspnea

It can be a symptom of rare but serious side effects like pancreatitis or gallbladder problems