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Drug Interactions The concomitant use of XIGDUO XR with specific drugs may increase the risk of metformin-associated lactic acidosis: those that impair renal function, result in significant hemodynamic change, interfere with acid-base balance or increase metformin accumulation (e.g., cationic drugs) [see DRUG INTERACTIONS ]

The risk of (temporary) minor incontinence is increased with weak muscle pressure and in women of advanced age and after several deliveries

Although traditionally considered to have no discernable effect on serum thyroid hormone concentrations, propranolol may inhibit peripheral conversion of T4 to T3

Patton JS, Fishburn CS, Weers JG

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Choline deficiency causes hepatic steatosis (fatty liver disease) and leads to loss of muscle membrane integrity