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Hydration: Staying well-hydrated throughout the day is important to avoid dehydration and reduce the risk of cramps

Therefore, if a new oral drug in development is intended to be co-administered with a GLP-1 agonist, we highly recommend conducting a healthy volunteer drug-drug interaction prior to Phase 3 trials to characterize the impact on the PK of the candidate new drug

PMID 28861405

Am J Clin Nutr 2011;94:348S-58S

However, this stance ignores the reality that approximately 70% of people with prediabetes never receive structured behavioral counseling, and many face barriers to sustained diet and exercise changes

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