10.1097/MPA.0b013e318214812b 60 SilvaM
The primary endpoint (reduction in fibrosis 1 stage without worsening of MASH at 36 weeks) showed no significant differences: 13% with placebo, 18% with 28 mg, and 19% with 50 mg
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It does not disrupt the interaction between dimers in the glutaminase tetramer but binds to the hydrophobic pocket between the monomer-monomer interface of the GAC, located at the junction where the N-terminal and C-terminal of the enzyme meet the catalytic domain, thereby preventing the GAC from activating conformational changes (Wilson et al., 2013
Improves Blood Sugar Control: By increasing insulin secretion (and reducing glucagon), GLP-1s help regulate blood glucose levels
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