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Early studies have found the medication to be either undetectable or present in extremely small amounts in breast milk , with no reported side effects in infants

Initial results from studies in rodents suggested a synergistic role of dual GLP-1 and glucagon agonism on reducing food intake and led to the development of numerous unimolecular GLP-1/glucagon co-agonists

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Figure 2 Within the central nervous system, GLP-1RAs function to reduce hunger sensations, suppress appetite, lower caloric intake, amplify satiety, and facilitate better management of eating behaviors (98102)

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