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On the other hand, phenolic compounds can act as mitocans through different mechanisms that include inhibition of HK-II, BCL-2, electron transport chain complexes, induction of oxidative stress, voltage-gated anion channel (VDAC)/adenine nucleotide translocase (ANT) complex dysregulation, or as lipophilic cations targeting the inner mitochondrial membrane, some intermediates of the TCA cycle, or mitochondrial DNA (Guerra et al., 2018)

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