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[1] [3] Key risk factors for developing hypotension on GLP-1 therapy include: Concurrent use of antihypertensive medications, especially diuretics, ACE inhibitors, or ARBs Concomitant use of SGLT2 inhibitors, which can cause osmotic diuresis and volume depletion Baseline blood pressure in the low-normal range (systolic 90-110 mmHg) Advanced age (65 years and older) Autonomic dysfunction or diabetic neuropathy Rapid or substantial weight loss Inadequate fluid intake or gastrointestinal side effects causing dehydration Concomitant use of other medications that lower blood pressure Patients with type 1 diabetes using off-label GLP-1 therapy or those with longstanding type 2 diabetes and cardiovascular autonomic neuropathy may be at higher risk for orthostatic hypotension

You can also use the front of the thigh if you have adequate fat there, but the outer aspect is preferred because the subcutaneous layer tends to be thicker

Tirzepatide (Mounjaro, Zepbound), a dual GIP and GLP-1 receptor agonist approved by the FDA for type 2 diabetes and chronic weight management, does not directly interact with anesthetic agents

Temozolomide Drives Ferroptosis via a DMT1-Dependent Pathway in Glioblastoma Cells

Decreased water retention

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