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3.2 Gastrointestinal barriers The intestinal epithelium is a single layer of cells lined the gut lumen that acts as a barrier to prevent injurious, intraluminal entities as well as microorganisms, toxins, foreign antigens, and allowing the translocation of essential electrolytes, dietary nutrients, and water from lumen into the circulation [16, 51, 72]

A gene-level shRNA score below 0 indicates reduced cell viability, equal to 0 indicates no effect on viability, and above 0 indicates enhanced viability

Keratosis pilaris usually appears during childhood or adolescence, and gradually improves with age

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Its anti-inflammatory mechanisms are enacted through the downregulation of pro-inflammatory cytokines such as IL-1, IL-6, and TNF-, along with the inhibition of NF-B signaling, thus alleviating neuroinflammation that is implicated in the etiology of depressive disorders (54)

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