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No loading phase is needed, and there's no evidence that tapering on or off changes outcomes

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The rest is either broken down in the gut or never absorbed

The receptor is a glycoprotein that, like all G protein-coupled receptors, has a seven-transmembrane helix domain and an N-terminal extracellular signal peptide [7]

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10.3390/microorganisms7010014 45 SarvanI.van der KlauwM.OlivieroT.DekkerM.VerkerkR