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Dogs receiving high-calorie intake (120% MER) exhibited a dose-dependent reduction in feed consumption and significant body weight decrease at doses of 236 mg and 492 mg of L-carnitine, independent of exercise, and this was mostly found in females

mTORC1 activity (pS6K1 Thr389) parallels pAkt kinetics: IGF-1 LR3 sustains pS6K1 elevation +1.82.4 at 48 h versus IGF-1s return to 1.11.3 at that timepoint

Previous weight loss medications targeted just one or two of these pathways

G., Molitor, C., Al-Oweini, R., Kortz, U

However, high doses may not provide extra benefits and should be avoided

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