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Although oxidative stress and necrosis were reported to be related to herbal products toxicities, the underlying mechanism is largely unknown (Stickel and Shouval, 2015)

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409 In Flinders Sensitive Line rats, which spontaneously develop depression-like phenotype, hippocampal GFAP-positive astrocytes are smaller and have atrophic arborisation

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When protonated to peroxynitrous acid (OONOH), it decomposes to yield the hydroxyl radical (Drge, 2002)