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In diet-induced obese mice, glucagon-driven energy expenditure depended on hepatic not adipose glucagon-receptor signaling and on sustained cAMP/PKA activation, and, strikingly, the energy-expenditure effect appeared in obese but not lean animals

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The relative abundance of bacterial taxa enriched in the endometrial microbiota of people with endometriosis belonged to the Actinobacteria phylum (Gram-positive), Oxalobacteraceae (Gram-negative) and Streptococcaceae (Gram-positive) families, and Tepidimonas (Gram-negative) genus, while those enriched in the symptomatic controls belonged to the Burkholderiaceae (Gram-negative) family, and Ralstonia (Gram-negative) genus

doi: 10.1016/J.MCNA.2006.07.009 38 DahalR

Pharmacokinetic and pharmacodynamic modeling of an anti-interleukin-6 chimeric monoclonal antibody (siltuximab) in patients with metastatic renal cell carcinoma